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Original Research Article | OPEN ACCESS

Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extract as an inhibitor of ?-MSH-mediated melanogenesis in B16F10 mouse melanoma cells

Ji Hyung Kim1, Hwa Jun Cha2

1SJ Natural Inc, Yong-in, South Korea; 2Osan University, Department of Beauty and Cosmetics, Osan, South Korea.

For correspondence:-  Hwa Cha   Email: hjcha@osan.ac.kr

Accepted: 26 May 2022        Published: 30 June 2022

Citation: Kim JH, Cha HJ. Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extract as an inhibitor of ?-MSH-mediated melanogenesis in B16F10 mouse melanoma cells. Trop J Pharm Res 2022; 21(6):1189-1193 doi: 10.4314/tjpr.v21i6.8

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To explore the anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extracts (KFFE) in B16F10 mouse melanoma cells.
Methods: The anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruit and leaf extracts (KFFE) were assessed using melanin contents assay and tyrosinase expression and activity assay in α-MSH-treated B16F10 mouse melanoma cells.
Results: The KFFE reduced α-MSH-mediated melanin synthesis in B16F10 mouse melanoma cells, while the tyrosinase mRNA expression was down-regulated by KFFE in B16F10 mouse melanoma cells (p < 0.05). Furthermore, cellular tyrosinase activity was downregulated by KFFE in B16F10 mouse melanoma cells (p < 0.05).
Conclusion: KFFE functions to repress melanin synthesis and thus, can potentially be used as a cosmetic ingredient.

Keywords: Lactobacillus kimchicus, Ficus caria, Melanogenesis, B16F10, Tyrosinase

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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